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Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups

7 Jul 2016

Abstract excerpt

BACKGROUND: Breast cancer is a heterogeneous disease comprising several biologically different types, exhibiting diverse responses to treatment. In the past years, gene expression profiling has led to definition of several "intrinsic subtypes" of breast cancer (basal-like, HER2-enriched, luminal-A, luminal-B and normal-like), and microarray based predictors such as PAM50 have been developed. Despite their...

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PMID: 27386846
DOI: 10.1186/s13058-016-0724-2

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