Article

Transcriptome-Based Subtype Discovery in Breast Cancer Using Variational Representation Learning

2026-08-04

Abstract excerpt

Breast cancer is a heterogeneous disease whose molecular complexity complicates therapeutic stratification. Although PAM50 is a widely used molecular subtyping framework, discrete subtype assignments may underrepresent transitional molecular states and within-subtype heterogeneity. We therefore developed a biologically interpretable representation-learning framework that projects bulk RNA-seq profiles into nonline...

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Literature Corpus work: f76fdf4c-46e5-5a0d-a6d5-c9c1040fde15
DOI: 10.20944/preprints202608.0225.v1

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