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Article

Single-nucleus and Spatially Resolved Intratumor Subtype Heterogeneity in Bladder Cancer

7 Apr 2023

Abstract excerpt

Background: Current bulk transcriptomic classification systems for bladder cancer do not consider the level of intratumor subtype heterogeneity. Objective: To investigate the extent and possible clinical impact of intratumor subtype heterogeneity across early and more advanced stages of bladder cancer. Design setting and participants: We performed single-nucleus RNA sequencing (RNA-seq) of 48 bladder tumors and...

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PMID: 37187723
DOI: 10.1016/j.euros.2023.03.006

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