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PRISM: recovering cell-type-specific expression profiles from individual composite RNA-seq samples

11 Mar 2021

Abstract excerpt

MOTIVATION: A major challenge in analyzing cancer patient transcriptomes is that the tumors are inherently heterogeneous and evolving. We analyzed 214 bulk RNA samples of a longitudinal, prospective ovarian cancer cohort and found that the sample composition changes systematically due to chemotherapy and between the anatomical sites, preventing direct comparison of treatment-naive and treated samples. RESULTS: To...

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PMID: 33720334
DOI: 10.1093/bioinformatics/btab178

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