Article

Cross-Platform Reproducible Modeling of Breast Cancer Prognosis Using the Core-PAM50 Gene Signature

2025-12-19

Abstract excerpt

<title>Abstract</title> <p>Background PAM50 is a widely adopted multigene signature for breast-cancer subtyping and prognosis, but cross-platform variability and incomplete gene coverage limit its portability. We developed a streamlined, platform-agnostic core-PAM50 panel (40 genes) and a fully documented pipeline to deliver reproducible prognostic modeling across major public cohorts. Methods Transcriptomes an...

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Literature Corpus work: 5ae0b85f-f3f6-5f37-a225-c92053d68f48
DOI: 10.21203/rs.3.rs-8048795/v1

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