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Article

Age-related alterations in plasma biomarkers of relevance to Alzheimer's disease are attenuated in KLOTHO KL-VS heterozygotes.

Journal of Alzheimer's disease : JAD - 1 Apr 2026

Driscoll Ira, Wilson Rachael E, Johnson Sterling C, Asthana Sanjay, Gallagher Catherine L, Hermann Bruce P, Sager Mark A, Carlsson Cynthia M, Blennow Kaj, Zetterberg Henrik, Dubal Dena B, Okonkwo Ozioma C

Abstract excerpt

BackgroundThe literature supports an attenuation of unfavorable age-related changes, in both cognitive performance and CSF biomarkers of significance to Alzheimer's disease (AD), in association with a functionally advantageous KLOTHO KL-VS genotype (KL-VSHET).ObjectiveTo examine whether KL-VSHET attenuation of unfavorable age-related biomolecular changes is detectable in AD-relevant plasma...

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Aging
Amyloid beta-Peptides
Glial Fibrillary Acidic Protein
Glucuronidase
Klotho Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurofilament Proteins

Peptide Fragments

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Identifiers

PMID: 41789852
DOI: 10.1177/13872877261422411

Genes

KL
GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Age-related alterations in plasma biomarkers of relevance to Alzheimer's disease are attenuated in KLOTHO KL-VS heterozygotes.PMID 41789852Read ↗

Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS HeterozygotesSemantic proximity Read ↗

KLOTHO KL‐VS heterozygosity is associated with diminished age‐related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adultsSemantic proximity Read ↗

KLOTHO heterozygosity attenuates APOE4 -related amyloid burden in preclinical ADSemantic proximity Read ↗

Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease riskSemantic proximity Read ↗

Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer’s DiseaseSemantic proximity Read ↗

Leveraging large multi-center cohorts of Alzheimer Disease endophenotypes to understand the role of Klotho heterozygosity on disease riskSemantic proximity Read ↗

Older more fit KL-VS heterozygotes have more favorable AD-relevant biomarker profilesSemantic proximity Read ↗

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.Semantic proximity Read ↗

KL-VS heterozygosity is associated with reduced tau accumulation and lower memory impairment in Alzheimer’s diseaseSemantic proximity Read ↗

Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4.Semantic proximity Read ↗

Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau BurdenSemantic proximity Read ↗

Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

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