Article

Targeting Adaptation to Cancer Treatment by Drug Combinations

2021-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Adaptation of tumors to therapeutic interventions contributes to dismal long-term patient outcomes. Adaptation to therapy involves co-action of functionally related proteins that together activate cell survival programs and compensate for the therapeutic impact. Oncogenic dependencies to such adaptive events, however, can generate new therapeutic vulnerabilities that can be targeted with drug co...

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Literature Corpus work: c939ca69-0f8d-5ffe-a6b4-51ed802a88d3
DOI: 10.1101/2021.04.14.439861

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