Article

Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations

2024-11-08

Abstract excerpt

Acute myeloid leukemia (AML) remains a formidable clinical challenge due to genetic heterogeneity, high relapse rates, and toxicities associated with conventional chemotherapies. Rationally designed drug combinations offer improved efficacy, yet their selection is often empirical and lacks molecular mechanistic understanding. Here, we present CoPISA workflow (Proteome Integral Solubility/Stability Alteration Analy...

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Literature Corpus work: 08b4827e-ffc7-52f2-976c-35702eaa35c2
DOI: 10.1101/2024.11.08.618644

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