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Durability of Kinase-Directed Therapies—A Network Perspective on Response and Resistance

12 Aug 2015

Abstract excerpt

Protein kinase-directed cancer therapies yield impressive initial clinical responses, but the benefits are typically transient. Enhancing the durability of clinical response is dependent upon patient selection, using drugs with more effective pharmacology, anticipating mechanisms of drug resistance, and applying concerted drug combinations. Achieving these tenets requires an understanding of the targeted kinase's...

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PMID: 26264276
DOI: 10.1158/1535-7163.mct-15-0088

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