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Article

Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence-Enabled Studies of Acute Phosphoproteomic Changes.

Molecular cancer therapeutics - 1 Jun 2022

Coker Elizabeth A, Stewart Adam, Ozer Bugra, Minchom Anna, Pickard Lisa, Ruddle Ruth, Carreira Suzanne, Popat Sanjay, O'Brien Mary, Raynaud Florence, de Bono Johann, Al-Lazikani Bissan, Banerji Udai

Abstract excerpt

We hypothesize that the study of acute protein perturbation in signal transduction by targeted anticancer drugs can predict drug sensitivity of these agents used as single agents and rational combination therapy. We assayed dynamic changes in 52 phosphoproteins caused by an acute exposure (1 hour) to clinically relevant concentrations of seven targeted anticancer drugs in 35 non-small cell lung cancer (NSCLC)...

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Identifiers

PMID: 35368084
DOI: 10.1158/1535-7163.MCT-21-0442
PMCID: PMC9381105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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