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Article

An oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies.

Cellular and molecular life sciences : CMLS - 10 Dec 2022

Orlando Eleonora, Medo Matúš, Bensimon Ariel, Quintin Aurélie, Riedo Rahel, Roth Selina M, Riether Carsten, Marti Thomas M, Aebersold Daniel M, Medová Michaela, Aebersold Ruedi, Zimmer Yitzhak

Abstract excerpt

PURPOSE: Oncogene addiction provides important therapeutic opportunities for precision oncology treatment strategies. To date the cellular circuitries associated with driving oncoproteins, which eventually establish the phenotypic manifestation of oncogene addiction, remain largely unexplored. Data suggest the DNA damage response (DDR) as a central signaling network that intersects with pathways associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36494469
DOI: 10.1007/s00018-022-04634-2
PMCID: PMC9734221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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