Article
TANDEM: a two-stage approach to maximize interpretability of drug response models based on multiple molecular data types.
Bioinformatics (Oxford, England) - 1 Sept 2016
Aben Nanne, Vis Daniel J, Michaut Magali, Wessels Lodewyk F A
Abstract excerpt
MOTIVATION: Clinical response to anti-cancer drugs varies between patients. A large portion of this variation can be explained by differences in molecular features, such as mutation status, copy number alterations, methylation and gene expression profiles. We show that the classic approach for combining these molecular features (Elastic Net regression on all molecular features simultaneously) results in models...
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