Article

CYP2D6 variants in amyotrophic lateral sclerosis: an association study of risk and survival

2025-10-06

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with limited therapeutic options. Riluzole remains the only widely available treatment in ALS, yet its benefits are modest and highly variable across patients. Genetic variation in cytochrome P450 2D6 (CYP2D6), a major enzyme in drug metabolism, detoxification of environmental toxins, and biotransformation of endogenous transmitters, h...

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Literature Corpus work: c93665b6-1416-5452-839c-e04ff43550d7
DOI: 10.1101/2025.09.29.25336320

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