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Article

Clinical and genetic characteristics of ALS patients with variants in genes regulating DNA methylation.

Journal of neurology - 1 Aug 2024

Yang Tianmi, Wei Qianqian, Pang Dejiang, Cheng Yangfan, Huang Jingxuan, Lin Junyu, Xiao Yi, Jiang Qirui, Wang Shichan, Li Chunyu, Shang Huifang

Abstract excerpt

BACKGROUND: Aberrant DNA methylation alterations are implicated in amyotrophic lateral sclerosis (ALS). Nevertheless, the influence of genetic variants in genes regulating DNA methylation on ALS patients is not well understood. Therefore, we aim to provide a comprehensive variant profile of genes related to DNA methylation (DNMT1, DNMT3A, DNMT3B, DNMT3L) and demethylation (TET1, TET2, TET3, TDG) and to...

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Identifiers

PMID: 38907861
DOI: 10.1007/s00415-024-12508-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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