Article
Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials.
Neurology - 31 Oct 2017
van Eijk Ruben P A, Jones Ashley R, Sproviero William, Shatunov Aleksey, Shaw Pamela J, Leigh P Nigel, Young Carolyn A, Shaw Christopher E, Mora Gabriele, Mandrioli Jessica, Borghero Giuseppe, Volanti Paolo, Diekstra Frank P, van Rheenen Wouter, Verstraete Esther, Eijkemans Marinus J C, Veldink Jan H, Chio Adriano, Al-Chalabi Ammar, van den Berg Leonard H, van Es Michael A
Abstract excerpt
OBJECTIVE: To assess whether genetic subgroups in recent amyotrophic lateral sclerosis (ALS) trials responded to treatment with lithium carbonate, but that the treatment effect was lost in a large cohort of nonresponders. METHODS: Individual participant data were obtained from 3 randomized trials investigating the efficacy of lithium carbonate. We matched clinical data with data regarding the UNC13A and C9orf72...
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