Article

Cell type directed design of synthetic enhancers

2022-07-27

Abstract excerpt

Transcriptional enhancers act as docking stations for combinations of transcription factors and thereby regulate spatiotemporal activation of their target genes. A single enhancer, of a few hundred base pairs in length, can autonomously and independently of its location and orientation drive cell-type specific expression of a gene or transgene. It has been a long-standing goal in the field to decode the regulatory...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c91f2f0a-c511-5782-a8e1-72e76f554c1b
DOI: 10.1101/2022.07.26.501466

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell type directed design of synthetic enhancersDOI 10.1101/2022.07.26.501466Read

Iterative deep learning-design of human enhancers exploits condensed sequence grammar to achieve cell type-specificitySemantic proximity Read

Evolutionary conditioning enables guided generation of functionally diverse enhancersSemantic proximity Read

DeepSTARR predicts enhancer activity from DNA sequence and enables the <i>de novo</i> design of enhancersSemantic proximity Read

Machine-guided design of synthetic cell type-specific <i>cis</i> -regulatory elementsSemantic proximity Read

Predictive design of tissue-specific mammalian enhancers that function <i>in vivo</i> in the mouse embryoSemantic proximity Read

Programming human cell type-specific gene expression via an atlas of AI-designed enhancersSemantic proximity Read

High-Activity Enhancer Generation based on Feedback GAN with Domain Constraint and Curriculum LearningSemantic proximity Read

EnhancerTracker: Comparing cell-type-specific enhancer activity of DNA sequence triplets via an ensemble of deep convolutional neural networksSemantic proximity Read

EnhancerDetector: Enhancer Discovery from Human to Fly via Interpretable Deep LearningSemantic proximity Read

Enhancer Identification using Transfer and Adversarial Deep Learning of DNA SequencesSemantic proximity Read

Deep learning-guided design of cell type-specific AAV promotersSemantic proximity Read

Mutagenesis Sensitivity Mapping of Human Enhancers In VivoSemantic proximity Read