Article

High-Activity Enhancer Generation based on Feedback GAN with Domain Constraint and Curriculum Learning

2023-12-17

Abstract excerpt

Enhancers are important cis-regulatory elements, enhancing the transcription of target genes. De novo design of high-activity enhancers is one of long-standing goals in generated biology for both clinical purpose and artificial life, because of their vital roles on regulation of cell development, differentiation, and apoptosis. But designing the enhancers with specific properties remains challenging, primarily due...

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Literature Corpus work: b4b26787-bf07-56cd-9152-7ad214390daf
DOI: 10.1101/2023.12.16.570150

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