Article

MiMSI - a deep multiple instance learning framework improves microsatellite instability detection from tumor next-generation sequencing

2020-09-18

Abstract excerpt

Microsatellite instability (MSI) is a critical phenotype of cancer genomes and an FDA-recognized biomarker that can guide treatment with immune checkpoint inhibitors. Recent work has demonstrated that next-generation sequencing data can be used to identify samples with MSI-high phenotype. However, low tumor purity, as frequently observed in routine clinical samples, poses a challenge to the sensitivity of existing...

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Literature Corpus work: c912bcfd-4c8e-5201-a7b4-6ffdcfa762df
DOI: 10.1101/2020.09.16.299925

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