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MSINGB: A Novel Computational Method Based on NGBoost for Identifying Microsatellite Instability Status from Tumor Mutation Annotation Data.

Interdisciplinary sciences, computational life sciences - 1 Mar 2023

Chen Jinxiang, Wang Miao, Zhao Defeng, Li Fuyi, Wu Hao, Liu Quanzhong, Li Shuqin

Abstract excerpt

Microsatellite instability (MSI), a vital mutator phenotype caused by DNA mismatch repair deficiency, is frequently observed in several tumors. MSI is recognized as a critical molecular biomarker for diagnosis, prognosis, and therapeutic selection in several cancers. Identifying MSI status for current gold standard methods based on experimental analysis is laborious, time-consuming, and costly. Although several...

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PMID: 36350503
DOI: 10.1007/s12539-022-00544-w

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