Article
Machine Learning Algorithm for the Detection of Tumor Microsatellite Instability Based on Multiomics Biomarkers.
JCO clinical cancer informatics - 1 Apr 2026
Strickland Kyle C, Wallen Zachary D, Pabla Sarabjot, Ko Heidi C, Previs Rebecca A, Green Michelle F, Hastings Stephanie, Dillard Alicia, Sathyan Pratheesh, Saini Kamal S, Jensen Taylor J, Caveney Brian J, Eisenberg Marcia, Ramkissoon Shakti, Severson Eric A
Abstract excerpt
PURPOSE: Accurate classification of microsatellite instability (MSI) in advanced cancers is critical for identifying patients who may benefit from immune checkpoint inhibitors. However, variability in MSI detection workflows can lead to missed MSI-high cases, indicating need for complementary screening approaches. Using next-generation sequencing (NGS) data from colorectal tumors, we developed a machine learning...
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