Article

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence

2024-04-13

Abstract excerpt

Bacteria have evolved a broad range of systems that provide defence against their viral predators, bacteriophages. Bacteriophage Exclusion (BREX) systems recognize and methylate 6 bp non-palindromic motifs within the host genome, and prevent replication of non-methylated phage DNA that encodes these same motifs. How BREX recognizes cognate motifs has not been fully understood. We have characterised BREX from patho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c8f7ffbd-1185-5499-9e06-5318f3f42831
DOI: 10.1101/2024.04.12.589231

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defenceDOI 10.1101/2024.04.12.589231Read

Mutations in the C-terminal region of the bacteriophage exclusion protein PglX can selectively inactivate restriction in Salmonella.Semantic proximity Read

Shield co-opts an RmuC domain to mediate phage defence across <i>Pseudomonas</i> speciesSemantic proximity Read

Molecular mechanism of quorum sensing inhibition in <i>Streptococcus</i> by the phage protein paratoxSemantic proximity Read

Molecular mechanism of quorum sensing inhibition in Streptococcus by the phage protein paratoxSemantic proximity Read

The phage protein paratox is a multifunctional metabolic regulator of <i>Streptococcus</i>Semantic proximity Read

Engineering selectivity of Cutibacterium acnes phages by epigenetic imprintingSemantic proximity Read

Phage detection by a bacterial NLR-related protein is mediated by DnaJSemantic proximity Read

A genetic dissection of the LlaJI restriction cassette reveals insights on a novel bacteriophage resistance system.Semantic proximity Read

The crystal structure of bacteriophage λ RexA provides novel insights into the DNA binding properties of Rex-like phage exclusion proteins.Semantic proximity Read

immX immunity region of rhizobium phage 16-3: two overlapping cistrons of repressor function.Semantic proximity Read

Structural insights into assembly, operation and inhibition of a type I restriction-modification system.Semantic proximity Read

Anti-mutagenic agent targeting LexA to combat antimicrobial resistance in mycobacteriaSemantic proximity Read