Structural insights into assembly, operation and inhibition of a type I restriction-modification system.

Abstract excerpt

Type I restriction-modification (R-M) systems are widespread in prokaryotic genomes and provide robust protection against foreign DNA. They are multisubunit enzymes with methyltransferase, endonuclease and translocase activities. Despite extensive studies over the past five decades, little is known about the molecular mechanisms of these sophisticated machines. Here, we report the cryo-electron microscopy...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cryoelectron Microscopy
• Share to DNA Restriction-Modification Enzymes