Article

Neurofilament Light Disordered Tail Mutations Reshape Its Self-Assembled Network Structure

2026-03-30

Abstract excerpt

Proteins with intrinsically disordered regions (IDRs) perform essential cellular functions despite lacking stable structures, challenging the traditional structure-function paradigm. Neurofilament-light (NFL) proteins assemble into bottlebrush filaments, whose disordered tail domains mediate nematic hydrogel formation critical for neuronal integrity. Mutations in NFL are linked to Charcot–Marie–Tooth (CMT) disease...

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Literature Corpus work: c8db6065-95cc-502e-8293-963b68afd99a
DOI: 10.64898/2026.03.27.714705

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