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Neurofilament Biophysics: From Structure to Biomechanics

10 Apr 2024

Abstract excerpt

Neurofilaments (NFs) are multisubunit, neuron-specific intermediate filaments consisting of a 10-nm diameter filament "core" surrounded by a layer of long intrinsically disordered protein (IDP) "tails." NFs are thought to regulate axonal caliber during development and then stabilize the mature axon, with NF subunit misregulation, mutation, and aggregation featuring prominently in multiple neurological diseases....

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PMID: 38598299
DOI: 10.1091/mbc.e23-11-0438

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