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Article

Neurofilament Light Disordered Tail Mutations Reshape Its Self-Assembled Network Structure.

Journal of the American Chemical Society - 5 Aug 2026

Aodeh Rawan, Dan Yoav, Yona Dean, Shalabi Mohammad, Sivan Asaf, Kravicas Mathar, Aharoni Hillel, Koren Gil, Adler-Abramovich Lihi, Beck Roy

Abstract excerpt

Proteins with intrinsically disordered regions (IDRs) perform essential cellular functions despite lacking stable structures, challenging the traditional structure-function paradigm. Neurofilament-light (NFL) proteins self-assemble into bottlebrush filaments, whose disordered tail domains mediate nematic hydrogel formation critical for neuronal integrity. Mutations in NFL are linked to Charcot-Marie-Tooth (CMT)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42479886
DOI: 10.1021/jacs.6c03785
PMCID: PMC13449960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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