Article

Coenzyme A depletion causes antibiotic tolerance in <i>Pseudomonas aeruginosa</i>

2025-10-24

Abstract excerpt

The widespread use of antibiotics promotes both resistance and tolerance. While resistance enables bacterial growth in the presence of drugs, tolerance allows survival during treatment, generating persisters that seed relapse and promote resistance. Despite its clinical relevance, the molecular basis of tolerance remains poorly understood. Using proteomic and metabolomic profiling combined with machine learning, w...

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Literature Corpus work: c8d973a3-3809-5c48-8c44-4a76d818878e
DOI: 10.1101/2025.10.24.684135

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