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Article

A scalable metabolite supplementation strategy against antibiotic resistant pathogen Chromobacterium violaceum induced by NAD+/NADH+ imbalance.

BMC systems biology - 26 Apr 2017

Banerjee Deepanwita, Parmar Dharmeshkumar, Bhattacharya Nivedita, Ghanate Avinash D, Panchagnula Venkateswarlu, Raghunathan Anu

Abstract excerpt

BACKGROUND: The leading edge of the global problem of antibiotic resistance necessitates novel therapeutic strategies. This study develops a novel systems biology driven approach for killing antibiotic resistant pathogens using benign metabolites. RESULTS: Controlled laboratory evolutions established chloramphenicol and streptomycin resistant pathogens of Chromobacterium. These resistant pathogens showed higher...

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Identifiers

PMID: 28446174
DOI: 10.1186/s12918-017-0427-z
PMCID: PMC5405553

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