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An <i>N,S</i> -acetylated L-cysteine-cysteamine conjugate hinders pyocyanin redox cycling to weaken <i>Pseudomonas aeruginosa</i> biofilm and dampens LPS-driven acute pulmonary inflammation

2026-05-15

Abstract excerpt

The persistence of P. aeruginosa infections is largely driven by the secretion of several factors during invasion, including the redox-active phenazine pyocyanin (PYO), which promotes biofilm formation and oxidative stress. Biofilms contribute to chronic infections and antibiotic resistance, limiting the efficacy of conventional therapies. We found that a synthetic compound, I-152, a conjugate of N-acetyl-L-cyste...

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Literature Corpus work
425ceef8-78eb-5da5-8e10-a3435cc0d937
DOI
10.64898/2026.05.13.724891
Open publication

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An <i>N,S</i> -acetylated L-cysteine-cysteamine conjugate hinders pyocyanin redox cycling to weaken <i>Pseudomonas aeruginosa</i> biofilm and dampens LPS-driven acute pulmonary inflammationDOI 10.64898/2026.05.13.724891
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