Article

Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification

2024-07-26

Abstract excerpt

The first lineage allocation in mouse and human embryos separates the inner cell mass (ICM) from the outer trophectoderm (TE). This symmetry breaking event is executed through polarization of cells at the 8-cell stage and subsequent asymmetric divisions, generating polar (TE) and apolar (ICM) cells. Here, we show that embryo polarization is unexpectedly asynchronous. Cells polarizing at the early and late 8-cell s...

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Literature Corpus work: c8c55954-8a12-5340-8eb7-0448fa223964
DOI: 10.1101/2024.07.26.605266

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