Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1

24 May 2023

Abstract excerpt

STUDY QUESTION: Which processes and transcription factors specify the first and second lineage segregation events during human preimplantation development? SUMMARY ANSWER: Differentiation into trophectoderm (TE) cells can be initiated independently of polarity; moreover, TEAD1 and YAP1 co-localize in (precursor) TE and primitive endoderm (PrE) cells, suggesting a role in both the first and the second lineage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hippo pathway signaling and YAP/TAZ
Share to Pluripotent Stem Cells Research
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37295962
DOI: 10.1093/humrep/dead107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1PMID 37295962Read ↗

Totipotency and lineage segregation in the human embryoSemantic proximity Read ↗

Revisiting trophectoderm-inner cell mass lineage segregation in the mammalian preimplantation embryoSemantic proximity Read ↗

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryoSemantic proximity Read ↗

Mechanism of cell polarisation and first lineage segregation in the human embryoSemantic proximity Read ↗

Evidence implicating sequential commitment of the founder lineages in the human blastocyst by order of hypoblast gene activationSemantic proximity Read ↗

Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development.Semantic proximity Read ↗

Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.Semantic proximity Read ↗

Spatio-temporal analysis of human preimplantation development reveals dynamics of epiblast and trophectodermSemantic proximity Read ↗

Evidence implicating sequential commitment of the founder lineages in the human blastocyst by order of hypoblast gene activationSemantic proximity Read ↗

Human pre-implantation embryo developmentSemantic proximity Read ↗

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centreSemantic proximity Read ↗

Early cell lineage specification in a marsupial: a case for diverse mechanisms among mammals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.