Article

Calcitonin Gene-related Peptide Attenuated Discogenic Low Back Pain by Inhibiting Microglia Activation Through the NLRP3/caspase-1 Signaling Pathway

2022-01-28

Abstract excerpt

<title>Abstract</title> <p>Discogenic low back pain (DLBP) is a multifactorial disease, associated with intervertebral disc degeneration. Calcitonin gene-related protein (CGRP) plays a critical role in pain processing, while the role in DLBP remains unclear. This study aims to investigate the anti-nociceptive role and related mechanisms of CGRP in DLBP. Here we established the DLBP rat and validated the model usi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c8758227-504f-5a87-b135-7b34b96e627d
DOI: 10.21203/rs.3.rs-1289899/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Calcitonin Gene-related Peptide Attenuated Discogenic Low Back Pain by Inhibiting Microglia Activation Through the NLRP3/caspase-1 Signaling PathwayDOI 10.21203/rs.3.rs-1289899/v1Read

The peripheral and central expression of CGRP and IB4 in chronic pain from MIA-induced TMJOA ratsSemantic proximity Read

Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation.Semantic proximity Read

Neuroinflammatory Biomarkers in Chronic Low Back Pain: Mechanisms, Clinical Evidence, and Translational ChallengesSemantic proximity Read

Crotalphine Modulates Microglia M1/M2 Phenotypes and Induces Spinal Analgesia Mediated by Opioid-Cannabinoid Systems.Semantic proximity Read

Voluntary Exercise Ameliorates Neuropathic Pain by Suppressing Calcitonin Gene-Related Peptide and Ionized Calcium-Binding Adapter Molecule 1 Overexpression in the Lumbar Dorsal Horns in Response to Injury to the Cervical Spinal CordSemantic proximity Read

Assessing the Potential Anti-Neuroinflammatory Effect of Minocycline in Chronic Low Back Pain: Protocol for a randomized, double-blind, placebo-controlled trialSemantic proximity Read

Mechanisms of low back pain: a guide for diagnosis and therapySemantic proximity Read

P2X4R+ microglia drive neuropathic pain.Semantic proximity Read

Inflammatory pain mediated by a phenotypic switch in brain-derived neurotrophic factor-immunoreactive dorsal root ganglion neurons innervating the lumbar facet joints in rats.Semantic proximity Read

Direct application of the TNF-alpha inhibitor, etanercept, does not affect CGRP expression and phenotypic change of DRG neurons following application of nucleus pulposus onto injured sciatic nerves in rats.Semantic proximity Read

Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype.Semantic proximity Read

Microglial pannexin-1 channel activation is a spinal determinant of joint painSemantic proximity Read