Article
Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype.
Molecular pain - 1 Jan 2000
Huo Wenwen, Zhang Ying, Liu Yue, Lei Yishan, Sun Rao, Zhang Wei, Huang Yulin, Mao Yanting, Wang Chenchen, Ma Zhengliang, Gu Xiaoping
Abstract excerpt
Bone cancer pain remains a major challenge in patients with primary or metastatic bone cancer due to a lack of understanding the mechanisms. Previous studies have revealed the two distinct functional polarization states of microglia (classically activated M1 and alternatively activated M2) in the spinal cord in nerve injury-induced neuropathic pain. However, whether microglia in the spinal cord polarize to M1 and...
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