Article
Direct application of the TNF-alpha inhibitor, etanercept, does not affect CGRP expression and phenotypic change of DRG neurons following application of nucleus pulposus onto injured sciatic nerves in rats.
Spine - 15 Oct 2008
Norimoto Masaki, Ohtori Seiji, Yamashita Masaomi, Inoue Gen, Yamauchi Kazuyo, Koshi Takana, Suzuki Munetaka, Orita Sumihisa, Eguchi Yawara, Sugiura Ai, Ochiai Nobuyasu, Takaso Masashi, Takahashi Kazuhisa
Abstract excerpt
STUDY DESIGN: Immunohistological and behavioral analysis of the effect of a tumor necrosis factor alpha (TNF-alpha) inhibitor in an injured-nerve model. OBJECTIVE: To examine the effect of direct application of a TNF-alpha inhibitor (etanercept) on injured-nerve pain caused by nucleus pulposus. SUMMARY AND BACKGROUND DATA: TNF-alpha is thought to play a crucial role in radicular pain. Calcitonin gene-related...
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