Article
Single-Cell Analysis in Cancer Genomics.
Trends in genetics : TIG - 1 Oct 2015
Saadatpour Assieh, Lai Shujing, Guo Guoji, Yuan Guo-Cheng
Abstract excerpt
Genetic changes and environmental differences result in cellular heterogeneity among cancer cells within the same tumor, thereby complicating treatment outcomes. Recent advances in single-cell technologies have opened new avenues to characterize the intra-tumor cellular heterogeneity, identify rare cell types, measure mutation rates, and, ultimately, guide diagnosis and treatment. In this paper we review the...
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