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Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells

1 Aug 2019

Abstract excerpt

Human bone marrow stromal cells (BMSC) are key elements of the hematopoietic environment and they play a central role in bone and bone marrow physiology. However, how key stromal cell functions are regulated is largely unknown. We analyzed the role of the immediate early response transcription factor EGR1 as key stromal cell regulator and found that EGR1 was highly expressed in prospectively-isolated primary...

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PMID: 31371413
DOI: 10.3324/haematol.2019.216648

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