Article

Stromal and Endothelial Transcriptional Changes during Progression from MGUS to Myeloma and after Treatment Response

2024-04-25

Abstract excerpt

<h4>ABSTRACT</h4> The role of the non-immune bone marrow microenvironment (BME) in the transition from monoclonal gammopathy of undetermined significance (MGUS) into clinically active multiple myeloma (MM) remains incompletely defined. To address this, we transcriptionally profiled endothelial cells (EC), mesenchymal stem cells (MSC) and MM cells at single-cell resolution from two genetically engineered mouse mod...

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Literature Corpus work: 4111bc47-bd96-58f5-b2fa-c0833a9cd6e1
DOI: 10.1101/2024.04.24.589777

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