Article

RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma

2021-10-16

Abstract excerpt

Radiation therapy induces cytotoxic DNA damage, which results in cell-cycle arrest and activation of cell-intrinsic death pathways, but its application has been limited by the radioresistance of tumors, such as in malignant melanoma. RIG-I is a cytosolic immune receptor expressed in all somatic cells, including tumor cells, with a key role in sensing viral RNA. RIG-I specific oligonucleotide ligands elicit a robus...

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Literature Corpus work: c858d16b-89c8-53d7-ba15-6ffbe1942caa
DOI: 10.1101/2021.10.16.464638

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