Article

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-κB-regulated immune response

2023-12-22

Abstract excerpt

Oncolytic Reovirus type 3 Dearing (RT3D), is a naturally occurring double-stranded (ds) RNA virus that is under development as an oncolytic immunotherapy We used an unbiased high-throughput cytotoxicity screen of different targeted therapeutic agents with the aim of identifying potential drug-viral sensitizers to enhance RT3D tumour killing. Talazoparib, a clinical poly(ADP)-ribose polymerase 1 (PARP-1) inhibitor,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25da2f3b-40c9-5a53-8849-7dd83c9abcc6
DOI: 10.1101/2023.12.21.572541

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-κB-regulated immune responseDOI 10.1101/2023.12.21.572541Read

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cellsSemantic proximity Read

Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling.Semantic proximity Read

RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanomaSemantic proximity Read

IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activitySemantic proximity Read

A modified oncolytic measles virus exhibits strong immunotherapeutic potential through RIG-I activation by defective viral genomesSemantic proximity Read

BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress.Semantic proximity Read

OvirusTdb: A database of oncolytic viruses for the advancement of therapeutics in cancerSemantic proximity Read

The oncolytic virus ΔPK has multimodal anti-tumor activity.Semantic proximity Read

Activated Ras Signaling Pathways and Reovirus Oncolysis: An Update on the Mechanism of Preferential Reovirus Replication in Cancer CellsSemantic proximity Read

Molecular Pathways: Mechanism of Action for Talimogene Laherparepvec, a New Oncolytic Virus ImmunotherapySemantic proximity Read

Tumor cell intrinsic RIG-I activation co-opts the host microenvironment to drive immune mediated tumor rejectionSemantic proximity Read

Single-cell data-driven design of armed oncolytic virus to boost cooperative innate-adaptive immunity against cancerSemantic proximity Read