Article

Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotype

2025-01-08

Abstract excerpt

Maternal immune activation (MIA) triggers an IL-17-driven autism spectrum disorder (ASD) in mouse and human offspring. While regulatory T cells (Tregs) regulate Th17 cells, their involvement in MIA and ASD pathogenesis is unknown. At the maternal level, we show that Treg stimulation suppresses interleukin-17 (IL-17) production and prevents ASD-like behaviors in offspring. At the offspring level, we show that MIA i...

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Literature Corpus work: 0bb96e96-71a6-561e-966a-8620ee0c9d31
DOI: 10.1101/2025.01.06.631430

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