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Article

Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice

31 Jul 2018

Abstract excerpt

Key Points Crbn I391V mice degrade known thalidomide derivative targets and recapitulate thalidomide-induced cytopenias and teratogenicity. Degradation of Ck1α is sufficient to explain the in vivo therapeutic window of lenalidomide in del(5q) myelodysplastic syndrome.

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PMID: 30064974
DOI: 10.1182/blood-2018-05-852798

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