Article

Oncogenic <i>Ppm1d</i> mutations deregulate the p53 pathway in primary mouse gliomas

2025-11-28

Abstract excerpt

<h4>Importance of Study</h4> Protein phosphatase magnesium-dependent 1D (PPM1D) is frequently mutated in diffuse midline gliomas (DMGs). DMGs are rare pediatric brain tumors with limited treatment options. Due to the cancer’s rapid progression, patients usually survive 12-24 months after diagnosis. This underscores the critical need to better understand the molecular mechanisms driving DMGs. This study describes...

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Literature Corpus work: 33473861-b7f8-542f-bd83-313fe3ef88ec
DOI: 10.1101/2025.11.25.690483

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