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Article

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate.

Nature chemical biology - 1 Oct 2018

Matyskiela Mary E, Couto Suzana, Zheng Xinde, Lu Gang, Hui Julia, Stamp Katie, Drew Clifton, Ren Yan, Wang Maria, Carpenter Aaron, Lee Chung-Wein, Clayton Thomas, Fang Wei, Lu Chin-Chun, Riley Mariko, Abdubek Polat, Blease Kate, Hartke James, Kumar Gondi, Vessey Rupert, Rolfe Mark, Hamann Lawrence G, Chamberlain Philip P

Abstract excerpt

Targeted protein degradation via small-molecule modulation of cereblon offers vast potential for the development of new therapeutics. Cereblon-binding therapeutics carry the safety risks of thalidomide, which caused an epidemic of severe birth defects characterized by forelimb shortening or phocomelia. Here we show that thalidomide is not teratogenic in transgenic mice expressing human cereblon, indicating that...

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PMID: 30190590
DOI: 10.1038/s41589-018-0129-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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