Article

Loss of INI1 inhibits the expression of SIDT1 and promotes tumor progression in skull base chordoma by regulating EZH2-mediated H3K27me3

2022-09-07

Abstract excerpt

<title>Abstract</title><p>Integrase interactor 1 (INI1) loss is associated with a poor prognosis of skull base chordoma, while the molecular mechanism remains generally unclear. Hence, we herein explored the regulatory mechanism underlying INI1 action in skull base chordoma. We exploited transcriptomic sequencing of 48 skull base chordomas to analyze the<italic>INI1</italic>-correlated genes, and we found that<ita...

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Literature Corpus work: c840d56c-d967-5b20-b38d-f0fc22198dcd
DOI: 10.21203/rs.3.rs-1995178/v1

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