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Article

Genomic aberrations frequently alter chromatin regulatory genes in chordoma.

Genes, chromosomes & cancer - 1 Jul 2016

Wang Lu, Zehir Ahmet, Nafa Khedoudja, Zhou Nengyi, Berger Michael F, Casanova Jacklyn, Sadowska Justyna, Lu Chao, Allis C David, Gounder Mrinal, Chandhanayingyong Chandhanarat, Ladanyi Marc, Boland Patrick J, Hameed Meera

Abstract excerpt

Chordoma is a rare primary bone neoplasm that is resistant to standard chemotherapies. Despite aggressive surgical management, local recurrence and metastasis is not uncommon. To identify the specific genetic aberrations that play key roles in chordoma pathogenesis, we utilized a genome-wide high-resolution SNP-array and next generation sequencing (NGS)-based molecular profiling platform to study 24 patient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27072194
DOI: 10.1002/gcc.22362
PMCID: PMC5031498

Genes

SETD2
BAP1
PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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