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Leukemia Inhibitory Factor Promotes Aggressiveness of Chordoma

1 Mar 2017

Abstract excerpt

Chordomas are rare tumors of the spine and skull base that are locally destructive and resistant to chemotherapy and radiation therapy, with a poor prognosis and limited therapeutic options. Chordoma patients have a long life expectancy with high mortality from the disease. Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential and are responsible for...

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PMID: 28247842
DOI: 10.3727/096504017x14874349473815

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