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Article

High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis.

Neoplasia (New York, N.Y.) - 1 Sept 2012

Diaz Roberto Jose, Guduk Mustafa, Romagnuolo Rocco, Smith Christian A, Northcott Paul, Shih David, Berisha Fitim, Flanagan Adrienne, Munoz David G, Cusimano Michael D, Pamir M Necmettin, Rutka James T

Abstract excerpt

Chordoma is a rare tumor arising in the sacrum, clivus, or vertebrae. It is often not completely resectable and shows a high incidence of recurrence and progression with shortened patient survival and impaired quality of life. Chemotherapeutic options are limited to investigational therapies at present. Therefore, adjuvant therapy for control of tumor recurrence and progression is of great interest, especially in...

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Identifiers

PMID: 23019410
DOI: 10.1593/neo.12526
PMCID: PMC3459274

Genes

FHIT
MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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