Article

Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS

2022-06-19

Abstract excerpt

Enzymatic cleavage of IgG antibodies is a common strategy used by pathogenic bacteria to ablate immune effector function. The Streptococcus pyogenes bacterium secretes the protease IdeS and the glycosidase EndoS, which specifically catalyse cleavage and deglycosylation of human IgG, respectively. IdeS has received clinical approval for kidney transplantation in hypersensitised individuals, while EndoS has found a...

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Literature Corpus work: c830f2e3-d652-5a82-a52a-bbf17da43baa
DOI: 10.1101/2022.06.19.496714

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