Article

Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS

2022-08-24

Abstract excerpt

<title>Abstract</title> <p>Enzymatic cleavage of IgG antibodies is a common strategy used by pathogenic bacteria to ablate immune effector function. The <italic>Streptococcus pyogenes</italic> bacterium secretes the protease IdeS and the glycosidase EndoS, which specifically catalyse cleavage and deglycosylation of human IgG, respectively. IdeS has received clinical approval for kidney transplantation in hypersen...

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Literature Corpus work: 3d514651-abb4-5a45-a08e-e8d1aff0c8ca
DOI: 10.21203/rs.3.rs-1967646/v1

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