Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of Propeptide Cleavage on the Stability and Activity of a Streptococcal Immunomodulatory C5a Peptidase for Biopharmaceutical Development

5 Jul 2023

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Posttranslational modifications of proteins can impact their therapeutic efficacy, stability, and potential for pharmaceutical development. The Group A Streptococcus pyogenes C5a peptidase (ScpA) is a multi-domain protein composed of an N-terminal signal peptide, a catalytic domain (including propeptide), three fibronectin domains, and cell membrane-associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Resistance in Staphylococcus
Share to Neonatal and Maternal Infections
Share to Streptococcal Infections and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37406301
DOI: 10.1021/acs.molpharmaceut.3c00207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of Propeptide Cleavage on the Stability and Activity of a Streptococcal Immunomodulatory C5a Peptidase for Biopharmaceutical DevelopmentPMID 37406301Read ↗

Protease propeptide structures, mechanisms of activation, and functions.Semantic proximity Read ↗

Sharpening Host Defenses during Infection: Proteases Cut to the ChaseSemantic proximity Read ↗

C5a peptidase (ScpA) activity towards human type II and type III interferonsSemantic proximity Read ↗

The Role of Streptococcal Cell-Envelope Proteases in Bacterial Evasion of the Innate Immune SystemSemantic proximity Read ↗

Identification and study of Prolyl Oligopeptidases and related sequences in bacterial lineagesSemantic proximity Read ↗

Diversity, Structures, and Collagen-Degrading Mechanisms of Bacterial Collagenolytic Proteases.Semantic proximity Read ↗

Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidaseSemantic proximity Read ↗

Insight into the human pathodegradome of the V8 protease from Staphylococcus aureusSemantic proximity Read ↗

More than Just Protein Degradation: The Regulatory Roles and Moonlighting Functions of Extracellular Proteases Produced by Fungi Pathogenic for HumansSemantic proximity Read ↗

N-terminomics identifies widespread endoproteolysis and novel methionine excision in a genome-reduced bacterial pathogenSemantic proximity Read ↗

Identification and study of Prolyl Oligopeptidases and related sequences in bacterial lineagesSemantic proximity Read ↗

Mapping specificity, entropy, allosteric changes and substrates in blood proteases by a high-throughput protease screenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.