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Group A streptococcal SpeB modifies IgA through targeting regions other than the hinge

25 Mar 2025

Abstract excerpt

ABSTRACT Degradation of immunoglobulin (Ig) represents an important bacterial immune evasion strategy. For mucosal colonization, degradation of IgA is of particular importance, and many bacteria secrete specific IgA proteases that typically target the extended hinge region of IgA1. Such a specialized IgA protease has not yet been reported in Group A Streptococcus (GAS), despite its ability to successfully...

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PMID: 40130864
DOI: 10.1128/spectrum.02450-24

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